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September 19, 1980

Antibiotic Activity in Surgical Incisions: The Basis for Prophylaxis in Selected Operations

JAMA. 1980;244(12):1353-1354. doi:10.1001/jama.1980.03310120041021

Perioperative antibiotic administration to produce systemic effects reduces the frequency of operative wound infection in selected procedures. Controlled clinical trials now indicate that cephalothin sodium may not be effective in this role, whereas cephaloridine and cefazolin sodium have been beneficial. Review of estimates of incisional antibiotic concentrations taken during prospective patient studies display patterns compatible with these data. Each drug reaches acceptable incisional concentrations, which are relatively well maintained for cephaloridine and cefazolin; cephalothin disappears from human incisions so rapidly as to provide little wound protection in operations lasting more than one hour.

(JAMA 244:1353-1354, 1980)