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October 3, 1980

Increased Renal Perfusion and Kidney Size in Convalescent Burn Patients

Author Affiliations

From the US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Tex. Dr Wilmore is now with the Department of Surgery, Harvard Medical School, Boston.

JAMA. 1980;244(14):1588-1590. doi:10.1001/jama.1980.03310140046029

Renal blood flow was elevated in convalescent burn patients shortly before discharge (992±112 mL/min/sq m in burn patients vs 551±37 mL/min/sq m in normal subjects; mean±SE). Autopsy studies demonstrated that renal enlargement was a constant feature of patients after a prolonged hospital course; the kidneys of 28 patients who died after 60 days of hospitalization weighed 241±10 g vs 153±8 g in control subjects. The increase in renal weight was primarily related to cellular hypertrophy and hyperplasia. These physiological and morphological findings in thermally injured patients may be a form of renal work hypertrophy following increased protein catabolism accompanying severe injury.

(JAMA 244:1588-1590, 1980)