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October 10, 1980

Carcinoma at the Site of Herpes Simplex Infection

JAMA. 1980;244(15):1675. doi:10.1001/jama.1980.03310150015016

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To the Editor.—  The Journal recently published a letter entitled "Carcinoma at the Site of Herpes Simplex Infection" (243:2396, 1980). My letter is to note further the occurrence of such a situation. I personally had basosquamous carcinoma develop on two occasions. The first occurrence was approximately five or six years ago at the site of a vaccination for small pox that I had received for traveling. After the vaccination site did not heal for one year, I became suspicious and had it excised at the local university hospital. I was approximately 55 years old at that time.During the past year, a similar situation developed at the site of a localized herpes simplex infection that had occurred on my upper lip and had not healed for approximately one year. It was removed by a Mohs' surgical procedure at a local university center, and a diagnosis of basosquamous cell carcinoma was