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May 27, 1988

Neurologists Study Abnormal CSF, Stroke Associated With AIDS

JAMA. 1988;259(20):2957. doi:10.1001/jama.1988.03720200001001

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STROKE IS 40 times more likely to occur in persons under 45 years of age who are infected with the human immunodeficiency virus (HIV) than in similarly aged noninfected persons, according to a report presented to the American Academy of Neurology. Speaking recently in Cincinnati at the group's 40th annual meeting, John Engstrom, MD, chief resident in neurology at the University of California, San Francisco, reported on a study of 1600 white male homosexuals with acquired immunodeficiency syndrome (AIDS) in which the frequency of stroke occurrence was 1%. The rate in the general population 35 to 45 years of age is 25 per 100000 (0.025%).

Of 28 patients with severe neurological problems, Engstrom said, 13 had suffered cerebral infarction (stroke), 13 had transient neurological deficit, and two had both conditions. The youngest patient with stroke was 27 years old. Stroke was the initial manifestation of AIDS in nine of the