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October 17, 1980

Clinically Important Radiation-Associated Thyroid Disease: A Controlled Study

Author Affiliations

From the Eugene L. Saenger Radioisotope Laboratory, Department of Radiology (Drs Maxon, Saenger, Thomas, and Kereiakes and Ms Shafer), the Metabolism Division, Department of Internal Medicine (Dr Maxon), and the Division of Epidemiology and Biostatistics, Department of Environmental Health (Dr Buncher), University of Cincinnati College of Medicine; and the University of Cincinnati Computing Center (Ms McLaughlin).

JAMA. 1980;244(16):1802-1805. doi:10.1001/jama.1980.03310160018016

We evaluated 1,266 persons who had received external radiotherapy for benign diseases in childhood. The evaluation used detailed questionnaires completed by trained interviewers and neoplastic disease registry data. The control population included 958 age-, sex-, race-, and diseasematched persons who had not received radiotherapy and 9,865 family members of the two study groups. An excess number of clinically important thyroid neoplasms, both benign and malignant, was noted in the irradiated group.

(JAMA 244:1802-1805, 1980)