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May 7, 1982

Transfusion-Related Cytomegalovirus Infection Following Noncardiac Surgery

Author Affiliations

From the Biskind Pathology Research Laboratory, Harold Brunn Institute for Medical Research, and the Departments of Medicine and Pathology and Laboratory Medicine, Mt Zion Hospital and Medical Center, San Francisco.

JAMA. 1982;247(17):2389-2391. doi:10.1001/jama.1982.03320420039029

Clinically evident cytomegalovirus (CMV) infections developed in five patients after noncardiac surgery. Each of them had received several blood transfusions and had evidence of primary CMV infection. These five cases were identified in a single eight-month period, suggesting that this syndrome must be occurring with greater frequency than is commonly appreciated. Three of the five patients had undergone splenectomy, and review of the literature for documented cases of posttransfusion CMV mononucleosis following non-cardiac-bypass surgery disclosed an additional nine patients, five of whom had had splenectomies. This striking association suggests the possibility that the spleen plays a role in controlling the incidence or clinical manifestations of posttransfusion CMV infections. Alternatively, this association may only reflect the frequent requirement for many blood transfusions in this type of surgery.

(JAMA 1982;247:2389-2391)