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May 7, 1982

Skin Microbiology: Relevance to Clinical Infection

Author Affiliations

University of Illinois Peoria School of Medicine Peoria

JAMA. 1982;247(17):2423. doi:10.1001/jama.1982.03320420067043

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


This book reviews the enormous progress made in the field of skin bacteriology since 1965, largely stimulated by the important role of disabling skin infections in the Vietnam War and by the Food and Drug Administration review of over-the-counter (OTC) antimicrobial products.

Concern at FDA over hexachlorophene toxicity in 1972 led to formation of the OTC Antimicrobial I Panel, which reviewed antimicrobial ingredients designed for daily use in hand washing, surgical scrubs, and first aid products. Panel recommendations led to major changes in effectiveness and toxicity testing, with emphasis on controlled clinical trials (randomized and double-blind with adequate numbers of patients) and specific new procedures such as the glove juice test, detailed in the text.

Surprisingly, the book does not mention the OTC Antimicrobial II Panel (1974 to 1980), which continued the review of ingredients in OTC topical antibiotic, antifungal, and acne preparations. However, many of the issues faced by