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November 28, 1980

Dosage of Aspirin

JAMA. 1980;244(21):2414. doi:10.1001/jama.1980.03310210016009

To the Editor.—  The authors of the Aspirin Myocardial Infarction Study (AMIS) (243:661, 1980) state that the regular administration of aspirin in a dosage of 1.0 g/day does not reduce three-year mortality in patients with a history of myocardial infarction (MI). There is no reason to doubt this. They also say that aspirin is not recommended for routine use in patients who have survived an MI. There is reason to doubt this, however, since they used too much aspirin.In 1972 I suggested that men older than 20 years and women older than 40 years take one aspirin tablet per day on a long-term basis in the hope that this would lessen the progression of atherosclerosis.1 I chose this dosage because it was well known then that small doses of aspirin would decrease platelet aggregation for days. This proved to be close to the proper dosage. The authors of