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December 12, 1980

Prolactin and Sexual Function

JAMA. 1980;244(23):2608. doi:10.1001/jama.1980.03310230014010

To the Editor.—  Regarding the article by Spark and co-workers (243:750, 1980) about hormonal evaluation in sexually impotent men, we would like to emphasize some points, particularly about the role of prolactin on sexual function.In the years 1975 to 1979, we saw 134 patients complaining of sexual disturbances (ie, impotence or ejaculatio precox) of nonorganic origin who were referred to our endocrine unit. All patients had serum luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL), testosterone, and 17 β-estradiol routinely determined by specific radioimmunoassay methods (Biodata Serono Kits).In our series mean (±SE) serum LH and FSH concentrations were not significantly different from those obtained in normal subjects (LH, 11.5± 0.6 vs 11.2±1.4 mIU/mL; FSH, 8.1±0.6 vs 6.5±0.4 mIU/mL); abnormally high or low LH and FSH levels were recorded in only 5% and 7% of cases, respectively.Though the mean serum PRL concentration in basal conditions did not significantly