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May 21, 1982

Lidocaine Prophylaxis and Myocardial Infarction-Reply

JAMA. 1982;247(19):2662. doi:10.1001/jama.1982.03320440014018

In Reply.—  We apologize for not including details of the criteria that we used for accepting diagnoses of acute myocardial infarction. The criteria, which were modified from the World Health Organization,1 are briefly summarized as follows: unequivocal serial changes on the ECG or typical or atypical chest pain history, together with an equivocal ECG and elevated cardiac enzymes or a typical chest pain history and elevated cardiac enzymes with a normal ECG. Readers who want to know further details can obtain them by writing to us.Since our work was done to test the two hypotheses about anticoagulants and lidocaine, the various analytic subgroups were formed according to the principles used for arranging comparisons of patients and results in a randomized trial. We showed the "ancestors" of those subgroups to demonstrate how erroneous results can be obtained when observational data are analyzed without suitable attention to those principles. Our