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May 21, 1982

Prospective Study of a Family Cancer Syndrome

Author Affiliations

From the Clinical Epidemiology (Dr Li) and Environmental Epidemiology (Dr Fraumeni) Branches, National Cancer Institute, Bethesda, Md.

JAMA. 1982;247(19):2692-2694. doi:10.1001/jama.1982.03320440040031

Risk of cancer was studied prospectively in four families described in 1969 as having diverse neoplasms, especially breast cancer and soft-tissue sarcoma. Between 1969 and 1981, in ten of 31 surviving family members, there developed 16 additional cancers (expected, 0.5). There were five breast carcinomas, four soft-tissue sarcomas, and seven other cancers. In eight patients, multiple primary cancers developed, including three softtissue sarcomas and one mesothelioma at sites of prior radiotherapy.

(JAMA 1982;247:2692-2694)