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May 21, 1982

Cardiac Pharmacology

Author Affiliations

Queens Hospital Center Long Island Jewish-Hillside Medical Center Jamaica, NY State University of New York at Stony Brook


edited by R. Douglas Wilkerson (Physiologic and Pharmacologic Bases of Drug Therapy, vol 2, Stanley Greenberg and Thomas M. Glenn, eds), 447 pp, with illus, $52, New York, Academic Press Inc, 1981.

JAMA. 1982;247(19):2722. doi:10.1001/jama.1982.03320440062041

Wilkerson's Cardiac Pharmacology couples a fine description of basic cardiovascular pharmacology and physiology with a competent presentation of clinical aspects of cardiovascular diseases. The text concerns four major points: (1) intrinsic and neural control of cardiac function; (2) pharmacologic modification of cardiac function; (3) genesis and control of cardiac arrhythmias; and (4) pharmacologic modification of myocardial oxygen supply and demand.

The first section begins with the basics of myocardial contractility followed by a chapter on the role of the CNS as a "locus" for action of the drugs that influence cardiovascular function.

The chapters in the following three sections tend to be extremely successful in providing informative discussion of basic principles and in supplying practical "how-to" information. The chapter on evaluation of drug-induced alteration in myocardial contractility is a good review. The subject material on the physiological and pharmacologic basis for the use of vasodilators in heart failure (chapter 8)