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May 28, 1982

Effects of Cimetidine on the Elimination and Actions of Ethanol

JAMA. 1982;247(20):2819-2821. doi:10.1001/jama.1982.03320450053036

The influence of cimetidine hydrochloride (300 mg four times daily for seven days) on plasma ethanol concentrations and the subjective assessment of intoxication after a single oral dose of ethanol (0.8 g/kg) were investigated in a randomized double-blind placebo controlled study in six volunteers. Compared with the placebo, cimetidine produced a small increase in both the peak plasma ethanol level (from 146 ±5.2 to 163 ±7.6 mg/dL, mean±SEM SEM) and the area under the ethanol concentration time curve (from 717±17 to 771 ±44 mg/dLXhr). In addition, using a visual analogue scale, subjects rated themselves more intoxicated at their peak of intoxication while receiving cimetidine. These results suggest that cimetidine has a small effect on the handling of ethanol in humans.

(JAMA 1982;247:2819-2821)