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June 4, 1982


JAMA. 1982;247(21):2957-2959. doi:10.1001/jama.1982.03320460057022

Important advances that have had immediate and far-reaching application to the diagnosis and therapy of human disease continue to be made in the field of immunology. Perhaps the most significant advance in 1981 has been the explosive expansion of knowledge from the examination of T-lymphocyte subsets,1,2 which has resulted in a greater understanding of their involvement in the regulation of immune responses important in patient management. This knowledge has found applicability in several clinical entities, including allergic diseases, immune deficiency disorders, organ transplantation, infectious diseases, rheumatoid disorders, and malignancy.

Allergic Diseases  The discovery of IgE3,4 has helped the practicing physician to understand better the wide spectrum of symptoms presented by his allergic patients. This has permitted better means of diagnosis and therapy of the allergic diseases, including allergic rhinitis, asthma, eczema, urticaria, and gastrointestinal tract allergy. Two recent advances of considerable fundamental importance in allergic diseases have been the demonstration