Patients undergoing major vaginal surgery and treated with prophylactic antibiotics were assigned to two groups in which the effectiveness of preoperative vaginal preparation with povidone-iodine was compared with that of saline solution. There was no difference in postoperative morbidity between the two groups, although a few more infections occurred in the group treated with povidone-iodine. It is suggested that simple dilution of the quantity of bacteria in the vagina is all that is essential for adequate preoperative vaginal preparation.
Amstey MS, Jones AP. Preparation of the Vagina for SurgeryA Comparison of Povidone-Iodine and Saline Solution. JAMA. 1981;245(8):839–841. doi:10.1001/jama.1981.03310330029019
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