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April 10, 1981

Medical News

JAMA. 1981;245(14):1393-1401. doi:10.1001/jama.1981.03310390003001

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Premenstrual syndrome: an ancient woe deserving of modern scrutiny  Premenstrual syndrome (PMS) may be the newest women's health issue in the United States. Some severely affected women are now going public with their stories and are demanding treatment—including the controversial natural progesterone therapy used principally in England—from their physicians.Similarly, some clinicians have begun examining PMS more closely. The precise physiological mechanisms underlying the syndrome remain unclear, they say, but its origins must be recognized as somatic, not psychological. Although there appears to be no uniformly efficacious treatment for the relatively few women who are seriously impaired, many investigators believe that natural progesterone deserves further study.In a recent article in the American Journal of Obstetrics and Gynecology (1981;139:85-104), Robert L. Reid, MD, fellow, and S. S. C. Yen, MD, chairman, Department of Reproductive Medicine, School of Medicine, University of California, San Diego, summarize much of the existing body