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June 25, 1982

Failure of Ketoconazole in Cryptococcal Meningitis

JAMA. 1982;247(24):3349-3351. doi:10.1001/jama.1982.03320490047035

Ketoconazole was used to treat an indolent case of cryptococcal meningitis that had not completely responded to a course of standard therapy with amphotericin B and flucytosine. Despite treatment with 600 mg/day of ketoconazole for seven months and adequate serum and CSF concentrations, the patient suffered a relapse while still receiving the drug. After the relapse, the condition responded to a higher-than-standard dose course of amphotericin B and flucytosine.

(JAMA 1982;247:3349-3351)