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June 25, 1982

Drug Interactions: A Source Book of Adverse Interactions, Their Mechanisms, Clinical Importance and Management

Author Affiliations

Veterans Administration Medical Center Palo Alto, Calif


by Ivan H. Stockley, 495 pp, paper, $29.50, Oxford, England, Blackwell Scientific Publications; St Louis, Blackwell Mosby Book Distributors, 1981.

JAMA. 1982;247(24):3361. doi:10.1001/jama.1982.03320490057039

Awareness of drug interactions has become almost an obsession. Many of those cited in various collections are of little clinical importance or extremely rare. Almost all are bad, although one can think of several that are good and are exploited to great advantage. Those that are important or frequent are of great concern, for they may at best interfere with treatment and at worst cause disabling or fatal consequences.

This is the latest of a number of books directed mainly at providing a reference to which busy clinicians can turn to determine whether the drugs they are prescribing may interact in untoward ways. The author begins properly by pointing out the frailty of much of the data. With this warning in mind, the reader is introduced to the basic mechanisms of drug interactions. After this opening chapter, the remaining 20 chapters consider interactions between single drugs (alcohol) or classes of