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Article
November 25, 1988

Clinical Approach to Infection in the Compromised Host

Author Affiliations

Mayo Clinic Scottsdale, Ariz

Mayo Clinic Scottsdale, Ariz

JAMA. 1988;260(20):3068. doi:10.1001/jama.1988.03410200124044

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Abstract

There is perhaps no greater challenge facing the clinician than the diagnosis and treatment of infection in the immunologically impaired patient. Diagnosis is particularly difficult because disease may appear in bizarre or unusual guise when a patient is granulocytopenic, and traditionally rarely encountered pathogens may be the most common in such settings. Treatment can be particularly perplexing, and response to therapy delayed.

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Here is an up-to-date volume targeted to the needs of the practitioner. How does one approach the patient with granulocytopenia and nodular pulmonary infiltrates? How is that approach different if the infiltrates are interstitial? Is candidal meningitis a concern in the patient with the acquired immunodeficiency syndrome? If a skin biopsy shows acid-fast bacilli, what possibilities come to mind? With admirable clarity the authors—all highly regarded experts in their respective fields—present the

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