We are grateful for the interest that Mr Issitt and Dr Tomasulo have taken in our report and welcome the opportunity to respond to their letter.The patient presented a complex serological picture, which was abbreviated in the case report. She was studied by two American Association of Blood Banks reference laboratories during a period of several months in 1978. There was a difference of opinion as to whether the presence of anti-Jkb could be proved conclusively. The high-frequency antibody was thought initially to be anti-Joseph, but ultimately its specificity could not be determined. Anti-Lewisa, anti-Lewisb, and an additional unidentified antibody were suspected. Two months after the delayed hemolytic transfusion reaction, an IgG autoantibody, reacting less strongly with Rh mull cells, developed. The exact cause of the delayed hemolytic transfusion reaction could not be determined, and the reference laboratory recommended that transfusion be restricted to
Patten E. The Patient With Multiple Alloantibodies-Reply. JAMA. 1982;248(2):169–170. doi:10.1001/jama.1982.03330020015009
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