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July 16, 1982

Vascular Diseases: Current Controversies

JAMA. 1982;248(3):373-374. doi:10.1001/jama.1982.03330030071042

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The authors, Drs Philip N. Sawyer and Richard M. Stillman, have put together a monograph that attempts to interface basic biologic considerations with clinical applications in peripheral vascular diseases. Although the title suggests a focus on current controversies, it can be more aptly described as a summary of the authors' experiences in investigative as well as clinical management of patients suffering from various vascular disorders.

Part 1 of the monograph deals with the physiochemical properties of blood and blood conduits and the various pharmacologic agents that affect thrombosis and hemostasis. In this section, some interesting historical and experimental observations are presented relating physiochemical properties of blood and vessels to the eventual development of thrombosis. The two chapters dealing with anticoagulants and fibrinolytic agents review a large number of pharmacologic agents, both experimental and currently available, that have an effect on coagulation and clot lysis. Regrettably, the data presented in these