This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
We thank Drs Thase and Perel in suggesting that we add imipramine and other tricyclic antidepressants to the growing list of newer antiarrhythmic drugs. In our review, the intent was not to discuss all new antiarrhythmic drugs. Rather, it was to present, in a brief compass, the salient features of those compounds that have been studied somewhat extensively. For this reason, we did not describe the properties or the role of the tricyclic compounds pirmenol hydrochloride, cibenzoline, sotalol, clofilium phosphate, propafenone, or moricizine. Undoubtedly, ongoing studies will clarify the relative merits and roles of these compounds in the control of disorders of cardiac rhythm.
Nademanee K, Singh BN. Antiarrhythmic Effects of Tricyclic Antidepressants-Reply. JAMA. 1982;248(4):429. doi:10.1001/jama.1982.03330040023023
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: