Dr Rosenberg has two specific complaints about our meta-analysis. The first is that we were wrong to have made an assumption about the distribution of alcohol consumption among subjects in her study.1 Whether the presence of a slight degree of exposure misclassification merits disregarding the results of Rosenberg et al is a decision we will leave to the reader. We repeated our meta-analysis of the casecontrol data on alcohol consumption in relation to risk of breast cancer with the data of Rosenberg et al excluded and got a result virtually identical to that originally published. We would like to remind Dr Rosenberg that of the two control groups she included in her study, we included in the meta-analysis only the one that gave the smaller estimates of relative risk associated with alcohol.Dr Rosenberg's second complaint pertains to our exclusion of the study by Miller et al.
Longnecker MP, Berlin J, Orza M, Chalmers TC. Meta-analysis of Alcohol and Risk of Breast Cancer-Reply. JAMA. 1989;261(3):383. doi:10.1001/jama.1989.03420030057028
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