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July 23, 1982

Acute Lymphoblastic Leukemia in a Patient Receiving Penicillamine for Wilson's Disease

Author Affiliations

From the Clinical Epidemiology Branch, National Cancer Institute. National Institutes of Health, Bethesda, Md; and the Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore (Drs Gilman and Holtzman).

JAMA. 1982;248(4):467-468. doi:10.1001/jama.1982.03330040055032

Acute lymphoblastic leukemia developed in a girl with Wilson's disease after 37 months of high-dose penicillamine therapy. We postulate that penicillamine-induced alterations in host immunity may cause a predisposition to certain malignancies, similar to that which occurs in other acquired or inherited immunodeficiency states.

(JAMA 1982;248:467-468)