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August 6, 1982

Pathophysiology of Shock, Anoxia, and Ischemia

JAMA. 1982;248(5):595. doi:10.1001/jama.1982.03330050077042

This book is designed to provide a comprehensive picture of the areas of shock, ischemia, and anoxia, specifically covering new developments since 1965. It is divided into four sections, with 76 contributing authors.

Section 1 deals with basic pathophysiological alterations at the level of the cell and in the microcirculation. An additional chapter on disseminated intravascular coagulation is included. Alterations in transport of calcium and other ions are emphasized. The second section is devoted specifically to shock, primarily at the organ level, and to its current therapy. Endotoxic, hemorrhagic, and septic shock are covered along with shock models, the use of computer registries, and consideration of such therapeutic modes as fluorocarbons and hyperbaric oxygen. The lung as a shock organ is extensively covered. Unfortunately, similar coverage is not given to the heart.

Section 3 deals with injury to the CNS, both brain and spinal cord. While this topic seems to