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February 17, 1989

Resuscitation From Cardiac Arrest Using High-Dose Epinephrine

JAMA. 1989;261(7):989-990. doi:10.1001/jama.1989.03420070039015

To the Editor. —  I was most interested in the recent report by Drs Koscove and Paradis.1 I would like to comment on their references to work that the late J. S. Redding and I did more than 25 years ago, which are summarized in a small monograph.2We found that 1 mg of epinephrine worked well in resuscitating our dog models, which weighed about 10 kg each. In view of the extraordinary range of recommendations for human resuscitation in the contemporary literature, we tried this same dose in humans, and often it worked. I remember several children as young as 3 years old to whom 1 mg of epinephrine was given with good results. Our thought at that time was that a dose of 1 mg was to be the minimal initial dose for any adult.It may be of interest to recall that many cardiologists were