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February 17, 1989

AIDS in the Nervous System

JAMA. 1989;261(7):1067. doi:10.1001/jama.1989.03420070117044

The stated objective of the authors is to help physicians diagnose and manage the neurological complications of the acquired immunodeficiency syndrome (AIDS) and human immunodeficiency virus (HIV) infection. The reader will find that this book achieves the authors' goal and more.

The nervous system is one of the most frequently involved organ systems affected by HIV infection. Disorders of the brain, meninges, spinal cord, peripheral nerve, and muscle have all been associated with primary HIV infection or HIV-related secondary opportunistic infections and tumors. Such nervous system disorders have appeared in diverse clinical settings, ranging from the initial manifestations of HIV infection to a myriad of opportunistic infections in persons with AIDS. In addressing the frequency and diversity of neurological disease associated with HIV infection, the authors, one a clinical neurologist and the other a neuropathologist, have skillfully combined their expertise.

The book's seven chapters are "The Character of AIDS," "Epidemiology,"