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April 7, 1989

Pathogenesis and Immunity in Pertussis

Author Affiliations

Lloyd Noland Hospital and Health Centers Fairfield, Ala

Lloyd Noland Hospital and Health Centers Fairfield, Ala

JAMA. 1989;261(13):1981-1982. doi:10.1001/jama.1989.03420130151042

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This is a 482-page authoritative text with 31 contributors who are among the most active investigators in the field of pertussis from six countries including the United Kingdom (16), Canada (2), France (2), Norway (1), Japan (5), and the United States (5). In 21 chapters the authors comprehensively present relevant new information concerning all aspects of pertussis. Each chapter begins with a brief introduction for the nonspecialist and concludes with a bibliography that contains the most recently published literature and often key historical references. There is an excellent blending of scientific information with practical clinical and vaccine applications.

The first half of the book reviews the microbiology of Bordetella pertussis, including growth characteristics of the microorganism and its products. The combined technologies of transposon mutagenesis and recombinant DNA technology have catapulted our understanding of both the pathogenesis of pertussis and the molecular organization of the genes determining virulence. Most of