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Article
April 14, 1989

'Lp(a)' Joins Other Serum Cholesterol Lipoproteins as Risk Determinant

JAMA. 1989;261(14):2013-2014. doi:10.1001/jama.1989.03420140013002

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Abstract

ANOTHER LIPOPROTEIN has been added to the roster of serum cholesterol components to be reckoned with. According to recent reports, serum concentrations of lipoprotein(a), often referred to as "Lp(a)," may be just as important as those of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in determining risk for coronary heart disease.

At a recent American Heart Association science writers' seminar in Monterey, Calif, John J. Albers, PhD, reported that a study of men with coronary disease indicated that Lp(a) was a better predictor of severity than either LDL or HDL. Albers, who is research professor of medicine and pathology at the University of Washington School of Medicine, Seattle, said that he and colleague B. Greg Brown, MD, found that Lp(a) levels varied directly with degree of arterial stenosis, with 27% of more than 200 patients with extensive three-vessel disease having Lp(a) levels in the 95th percentile (1.25 mm/L or 48

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