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August 27, 1982

Dangers of Intravenous Ritodrine in Diabetic Patients

Author Affiliations

From the Departments of Medicine (Drs Mordes and Colwell) and Obstetrics and Gynecology (Dr Kreutner), the Medical University of South Carolina, Charleston; and the Department of Medicine, University of South Carolina, Columbia (Dr Metzger).

JAMA. 1982;248(8):973-975. doi:10.1001/jama.1982.03330080055030

Two cases are reported in which administration of ritodrine hydrochloride, a β-2-sympathomimetic agent, was followed by diabetic ketoacidosis when it was used for inhibition of premature labor in insulin-requiring diabetic patients. Ketoacidosis occurred shortly after intravenous ritodrine, despite previous administration of large subcutaneous doses of insulin. Early recognition and treatment of this serious complication are critical for fetal survival.

(JAMA 1982;248:973-975)