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September 10, 1982

Ceruletide in Postoperative Adynamic Ileus

JAMA. 1982;248(10):1181. doi:10.1001/jama.1982.03330100021020

To the Editor.—  In a recent issue of The Journal (1982;247:2152), in response to a question concerning small-bowel examinations and contrast material, Dr Thoeni provided a concise and excellent discussion of radiopaque contrast materials for evaluating the small bowel. He noted that ceruletide diethylamine (Tymtran) has been used to accelerate transit time in the small bowel during barium examination. However, he also stated that "its usefulness for treatment of postoperative adynamic ileus has not been proved." To the contrary, ceruletide has been shown to be effective in the treatment of intestinal atony both in postoperative patients and in patients with chronic fecal stasis in many studies from other countries.1-5 When ceruletide was administered to patients postoperatively, including patients who had resections of various portions of the gastrointestinal tract, resumption of bowel activity was twice as rapid as in the control group.5 No significant adverse effects were seen, even