Despite conventional antibiotic regimens with chloramphenicol and aminoglycosides, mortality from gram-negative bacillary meningitis approaches 40%. With the development of new antibiotics, therapy for this form of meningitis has become an active area of investigation. We describe successful treatment of Klebsiella pneumoniae meningitis with intravenous trimethoprim-sulfamethoxazole, documenting bactericidal levels of the drug in the CSF.
Hickstein DD, Dillon JT. Klebsiella pneumoniae Meningitis: Intravenous Trimethoprim-Sulfamethoxazole Treatment. JAMA. 1982;248(10):1212–1213. doi:10.1001/jama.1982.03330100050030
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