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The publication of laboratory research using animal models is of great importance, but it does not replace patient-based forms of clinical research as the cornerstone of a general medical journal. Yet, many of the most important advances in medical research of the past few decades have depended on laboratory investigations that did not involve human subjects. For practical and ethical reasons, many elegant and conceptually illuminating experiments can be done only with nonhuman models. A journal that ignores this area of research risks becoming irrelevant to a large audience of practitioners and physicians in training who are well versed in basic science concepts and who wish to maintain such an in-depth basis for their practice.
With this issue, The Journal will begin publishing a new section of fundamental laboratory investigation under the heading CLINICAL INVESTIGATIONS. These articles will typify more experimental and theoretical approaches to medical research than do many
Grouse LD, Lundberg GD. Clinical Investigations: A New Section for The Journal. JAMA. 1982;248(10):1218. doi:10.1001/jama.1982.03330100056034
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