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September 10, 1982

Cardiac Transplantation— 1982

JAMA. 1982;248(10):1225-1227. doi:10.1001/jama.1982.03330100061036

IT HAS been 14 years since the first human cardiac transplantation was performed. Early widespread enthusiasm was inappropriate; disappointing results led to an equally inappropriate pessimistic view. In the intervening decade, consistent effort at a few medical centers has gradually produced the evolutionary development that characterizes most medical progress. The changes in cardiac transplantation include refinement in patient selection, diagnosis and management of acute cardiac rejection, and treatment of complications.1 This has resulted in survival of close to 70% at one year and 50% at five years after transplantation at Stanford (Calif) Medical Center. These results give cardiac transplantation a definite role in the therapy of selected groups of patients who are terminally ill from cardiac disease. Recognition of this fact is reflected in the number of cardiac transplant procedures presently being performed, shown in Fig 1. The total number of cardiac transplantation procedures is again approaching 100 per