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September 10, 1982

Ultrastructural Pathology of the Cell and Matrix: A Text and Atlas of Physiological and Pathological Alterations in the Fine Structure of Cellular and Extracellular Components

JAMA. 1982;248(10):1245-1246. doi:10.1001/jama.1982.03330100071041

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For his inhospitality to Perseus, Atlas was forced to bear the burden of the heavens through eternity. Sisyphus, for his greater transgression, became responsible for repeatedly pushing a large stone up a hill and on nearing the summit having it escape his grasp and roll down. I don't know if Ghadially's task in producing his book was freely assumed or thrust upon him, but his labors seem closer to those of Sisyphus than Atlas. He has (in his own words) directed his efforts to "cataloging, classifying, describing and illustrating virtually every intracellular lesion." Each time he must think he is about to roll the last abnormality up his mountainous catalogue, a new group of changes comes rolling out of the journals.

I must admit to having had, at the time of the first edition in 1975, considerable reservation with respect to the usefulness of such a collection of deranged subcellular