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September 17, 1982

No bypass of clinical trial for EC/IC neurosurgery

JAMA. 1982;248(11):1287-1289. doi:10.1001/jama.1982.03330110005002

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Nearly 15 years ago, the first two recorded human extracranial/intracranial (EC/IC) arterial bypasses were performed 24 hours apart on opposite sides of the Atlantic by the operation's two developers. Now patient enrollment (1,500 patients) had been completed for an international study of the operation's effectiveness in reducing stroke incidence.

Sixty-five centers in North America, Europe, and Asia are involved, and funding comes from the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS), Bethesda, Md.

The bypass procedure involves anastomosis of the superficial temporal scalp artery to the middle cerebral artery through a skull opening to supplement the brain's blood supply.

According to S. J. Peerless, MD, professor and chairman, neurosurgery division, University of Western Ontario Faculty of Medicine, London, Canada, the study is trying to determine if a group of patients who appear to be at risk of a disabling or lethal ischemic stroke have a better prognosis