DURING the past decade, a number of studies have been performed in an attempt to improve our understanding of the factors responsible for the immunologic destruction of blood cells. These studies, which have used quantitative immunologic techniques, have led to an improved understanding of the pathophysiology of autoimmune hemolytic anemia and immune thrombocytopenic purpura, and to a more precise understanding of the effector mechanisms that are operable in immunohematologic disease. These studies have helped to identify those patients in clinical, but not yet in immunologic, remission and have helped in the treatment of those patients with persistent immunologic disease. Furthermore, these studies have helped to elucidate the mechanism of action of corticosteroids in immunohematologic disease and have enabled the clinician to diagnose more readily and monitor patients with immunohematologic disease. Additionally, these studies have led to an increased understanding of the pathophysiology of a new entity: immunologic infertility.
Schreiber AD. Immunohematology. JAMA. 1982;248(11):1380–1385. doi:10.1001/jama.1982.03330110068034
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