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September 24, 1982

Non-A, Non-B Hepatitis

JAMA. 1982;248(12):1512. doi:10.1001/jama.1982.03330120066041

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"Non-A, non-B (NANB) hepatitis" is a term that has been given to the viruses that cause hepatitis in man other than the well-characterized hepatitis viruses type A and B. Since these agents are of great clinical and public health importance, a volume summarizing current knowledge, most of which is of recent origin, was much needed. R. J. Gerety has admirably fulfilled this need by bringing together in one volume a collection of excellent reviews by active workers in this field.

These authors have reviewed the history, diagnosis, clinical course, and epidemiology of the disease and have described in detail the results of studies in experimentally infected chimpanzees, including a description of the light and electron microscope findings. The controversial and confusing area of putative NANB-specific antigens and particles is also carefully reviewed, although Gerety seems to be more optimistic regarding the specificity of immunofluorescent methods of NANB antigen detection than