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October 1, 1982

Trolamine Salicylate Cream in Osteoarthritis

JAMA. 1982;248(13):1578. doi:10.1001/jama.1982.03330130025011

To the Editor.—  A report by Algozzine et al, "Trolamine Salicylate Cream in Osteoarthritis of the Knee" (1982; 247:1311), conveys an erroneous impression on usefulness of 10% trolamine salicylate cream (also known as triethanolamine salicylate) in the treatment of rheumatic symptoms. The report found no significant differences between the trolamine salicylate and a placebo in the treatment of osteoarthritis in 25 male patients at a Veterans Administration Hospital in Florida.The results obtained by Algozzine et al are completely opposite to my findings1 that a topical salicylate cream (trolamine salicylate 10% ) was as effective as orally ingested aspirin in alleviating moderate to severe rheumatic pain in several different parts of the body.I found that the 10% trolamine salicylate cream was most effective when it was applied where there was acute or subacute pain, especially on non-weight-bearing joints and areas. Trigger points of pain caused by the nonarticular component of