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The comments and data presented by Dr Salit are very much appreciated. Unfortunately, neither of our two patients with SLE who were receiving steroids every other day were tested at the time of their illness for immunoglobulin or complement deficiency. However, I agree with Dr Salit that in the few patients described to date, there is a striking association of W135 meningococcal disease and immunosuppression, with or without immunoglobulin and complement deficiency, and such studies should be performed to document this association.
Roberts RB. Neisseria meningitidis Serogroup W135 Disease-Reply. JAMA. 1982;248(13):1581. doi:10.1001/jama.1982.03330130029020
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