The long-awaited second edition of Cancer Medicine by Holland and Frei has finally been published. The first edition, published in 1973, was the standard text for medical oncologists. Publication of an oncology text presents difficulties to the editors, for they must ensure that the "how to do and treat" aspects of oncology are clearly stated and reflect the state of the art. However, a strictly "how to" textbook would be inadequate, as it would omit a discussion of the biological principles that form the basis of oncology. Holland and Frei were well aware of the need for stating the principles in their first edition, and this second edition of Cancer Medicine, like the first, provides the reader with the basic principles of neoplasia: its etiology (124 pages); pathogenesis (76 pages); epidemiology (72 pages); and the basis of its treatment—surgery, radiotherapy, and chemotherapy (190 pages). Thus, in this text there is
Bitran J. Cancer Medicine. JAMA. 1982;248(13):1644. doi:10.1001/jama.1982.03330130092039
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