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October 8, 1982

Cancer: A Comprehensive Treatise, vol 1: Etiology, Chemical and Physical Carcinogenesis

JAMA. 1982;248(14):1762. doi:10.1001/jama.1982.03330140070047

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


The last three decades have seen considerable progress in the possibilities of primary prevention of human cancer. Not only have the major causes for a number of human cancers been identified (nearly 50% in US males), but also understanding of neoplastic mechanisms has increased enormously owing to developments in biochemistry and molecular biology. Such studies have, however, emphasized the complexities of carcinogenesis, the multistage nature of which is now influencing modern conceptual approaches to cancer control.

This revised second edition of the cancer series edited by Dr Becker is a useful introduction to the complexities of carcinogenesis and will be of value to young research workers who wish a broad approach. While the treatise cannot be regarded as complete, it contains useful chapters on recent developments not only in relation to classic studies on initiation, but also in relation to nonspecific modulators of carcinogenic factors and their influence on metabolic