Seventy-seven neonates weighing less than 1,500 g each were typed for HLA antigens. The phenotypes were correlated with the subsequent clinical course of the newborns. Forty-four (57%) of 77 newborns had an HLA-A2 antigen, whereas 194 (52%) of 376 unrelated adult controls possessed this same antigen. All 11 infants with roentgenographic evidence of chronic lung disease had HLA-A2 antigens, whereas 33 (50%) of 66 infants without HLA-A2 antigens did not have chronic lung disease. We conclude that the HLA-A2 antigen may be associated with susceptibility to chronic lung disease in newborns.
Clark DA, Pincus LG, Oliphant M, Hubbell C, Oates RP, Davey FR. HLA-A2 and Chronic Lung Disease in Neonates. JAMA. 1982;248(15):1868–1869. doi:10.1001/jama.1982.03330150054023
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