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October 22, 1982

Medical News

JAMA. 1982;248(16):1937-1948. doi:10.1001/jama.1982.03330160003001

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Not one but four possible oral vaccines for cholera under study  Four likely candidates for an oral vaccine intended to protect against cholera in Bangladesh and other areas where the severe diarrheal disease is endemic were discussed recently at an international symposium in Dublin sponsored by the World Health Organization.Far along at this point is "Texas Star," a live, chemically mutated version of the pathogen Vibrio cholerae which was developed about three years ago by Richard Finkelstein, PhD, and Takeshi Honda, PhD, when they were still at the University of Texas Southwestern Medical School in Dallas. (Finkelstein is now at the University of Missouri in Columbia, and Honda is at the Research Institute for Microbial Disease, Osaka, Japan.)The Texas Star mutant produces B subunit, that portion of the toxin molecule that binds to specific receptors on the intestinal mucosal cells and that is responsible for the cholera