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October 22, 1982

The Effect of Starvation and Repletion on Plasma Fibronectin in Man

Author Affiliations

From the Divisions of Combat Casualty Care (Dr Scott) and Blood Research (Drs Sohmer and MacDonald), Letterman Army Institute of Research, and the Department of Medicine, Letterman Army Medical Center (Dr MacDonald), Presidio of San Francisco. Dr Sohmer is now with St Thomas Hospital, Nashville, Tenn.

JAMA. 1982;248(16):2025-2027. doi:10.1001/jama.1982.03330160073028

Since circulating fibronectin levels have been associated with trauma, the relationship between fibronectin and fasting was investigated. Eighteen healthy but obese patients fasted for 21 days, and plasma fibronectin levels were determined weekly. Fibronectin concentrations were reduced throughout the fast, but increased after food intake. This starvation-induced decrease in fibronectin may be a deleterious mechanism associated with physiological insults.

(JAMA 1982;248:2025-2027)