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October 20, 1989

Measuring Compliance

JAMA. 1989;262(15):2091-2092. doi:10.1001/jama.1989.03430150051018

To the Editor.—  I have some questions and a comment for Cramer et al1 on their article entitled "How Often Is Medication Taken as Prescribed?"How do the Medication Event Monitoring Systems prevent or control for gratuitous bottle opening? How did you verify weekly full bottle pill counts, since the patient was asked to refill the Medication Event Monitoring Systems pill bottle? What were the patients' ages and perceived mental capacity in each group? (My experience is that free-living old and old-and-retarded persons comply less well than other groups.) How much do the Medication Event Monitoring Systems cost? Could they reasonably be applied to "difficult" patients in a free-living setting?It is my experience that many patients with seizures have complicated drug regimens, for example, 200 mg of carbamazepine (Tegretol) with 2 tablets taken in the morning and 3 tablets at bedtime. How do Medication Event Monitoring Systems ensure