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November 12, 1982

THC or analogues may alleviate some tremors

JAMA. 1982;248(18):2215. doi:10.1001/jama.1982.03330180009006

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Tetrahydrocannibinol (THC), a major active ingredient of marijuana, suppressed tremors in two of eight patients with multiple sclerosis (MS), reported neuropharmacologist David Clifford, MD, at the recent annual meeting of the American Neurological Association in Washington, DC.

In a study conducted at Washington University School of Medicine in St Louis, where Clifford is assistant professor of neurology, 5 mg of Δ9-THC was administered orally to eight MS patients suffering from disabling tremors and ataxia. The ages of the four men and four women ranged from 21 to 49 years. The dosages were increased by 5-mg increments everysix hours until therapeutic responses or adverse effects occurred. Samples of THC were obtained from the National Institute on Drug Abuse, Rockville, Md.

Subjective and objective improvement were reported in two of the eight patients; this did not occur when a placebo was used in the single-blinded experiment. Clifford said the most