A 51-year-old patient with acute myelogenous leukemia, who was alloimmunized to platelets, failed to show adequate platelet increments after receiving transfusions of HLA grade A-identical platelets. Only platelets from an HLA grade B-matching donor gave high increments. Several crossmatching procedures were used to select platelet donors. A correlation was seen between in vitro tests and in vivo response. HLA typing has limitations in the selection of platelet-compatible donors.
Hecht T, Wolf JL, Mraz L, Scott EP, Petz LD. Platelet Transfusion Therapy in an Alloimmunized Patient: The Value of Crossmatch Procedures for Donor Selection. JAMA. 1982;248(18):2301–2303. doi:10.1001/jama.1982.03330180061035
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