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Article
December 1, 1989

Systemic and Local Allergic Reactions to the Tine Test Purified Protein Derivative

Author Affiliations

University of South Florida College of Medicine James A. Haley Veterans Administration Hospital Tampa

University of South Florida College of Medicine James A. Haley Veterans Administration Hospital Tampa

JAMA. 1989;262(21):2999-3000. doi:10.1001/jama.1989.03430210037023
Abstract

To the Editor. —  The Tine Test Purified Protein Derivative (PPD) (Lederle Laboratories, Pearl River, NY) is an epicutaneous skin test used to assess cell-mediated immunity to tuberculosis. A systemic allergic reaction temporally following the administration of the Tine Test Old Tuberculin (Lederle) has been reported,1 but the following is the first report of such a reaction after the Tine Test PPD. Rare local allergic reactions to the test are an immediate wheal-flare reaction and/or a reaction of erythema and induration that peaks after 6 hours and subsides within 24 hours.2

Report of a Case.—  A 35-year-old white woman with a history of allergic rhinitis for 8 years and urticaria/angioedema due to shellfish ingestion for 9 years received a Tine Test PPD as part of a hospital employee health evaluation. She had received two intradermal Mantoux PPD tests 8 and 16 years previously without experiencing a reaction. She

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