To the Editor. —
The Tine Test Purified Protein Derivative (PPD) (Lederle Laboratories, Pearl River, NY) is an epicutaneous skin test used to assess cell-mediated immunity to tuberculosis. A systemic allergic reaction temporally following the administration of the Tine Test Old Tuberculin (Lederle) has been reported,1 but the following is the first report of such a reaction after the Tine Test PPD. Rare local allergic reactions to the test are an immediate wheal-flare reaction and/or a reaction of erythema and induration that peaks after 6 hours and subsides within 24 hours.2
Report of a Case.—
A 35-year-old white woman with a history of allergic rhinitis for 8 years and urticaria/angioedema due to shellfish ingestion for 9 years received a Tine Test PPD as part of a hospital employee health evaluation. She had received two intradermal Mantoux PPD tests 8 and 16 years previously without experiencing a reaction. She
Wright DN, Ledford DK, Lockey RF. Systemic and Local Allergic Reactions to the Tine Test Purified Protein Derivative. JAMA. 1989;262(21):2999–3000. doi:10.1001/jama.1989.03430210037023
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