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December 8, 1989

Striae and Systemic Abnormalities of Connective Tissue

JAMA. 1989;262(22):3132. doi:10.1001/jama.1989.03430220053024

To the Editor. —  Drs Glesby and Pyeritz1 include striae as one of the 18 signs of a possible systemic connective-tissue disorder. Thirty-four percent of their patients with a diagnosis of overlap connective-tissue disorder had striae. However, Pinkus et al2 found no significant difference in the striae of normal controls vs patients with Marfan syndrome, and Sisson3 examined 190 healthy children aged 10 to 16 years and found striae in 35% (28% of the boys and 71.6% of the girls). Given the high percentage of striae found in the normal population, it is hard to understand why Drs Glesby and Pyeritz included striae as one of their clinical criteria for diagnosing a systemic connective-tissue disorder (with all of the ramifications that label entails). The presence of striae seems to be nothing more than a random association.